Repair of Radiation Damage in Plateau-phase Mammalian Cells: Relationship Between Sub-lethal and Potentially Lethal Damage States
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چکیده
منابع مشابه
Relationship between the repair of radiation-induced DNA damage and recovery from potentially lethal damage in 9L rat brain tumor cells.
The kinetics of repair of radiation-induced DNA damage and recovery from radiation-induced potentially lethal damage (PLD) for fed plateau-phase 9L/Ro rat brain tumor cells were compared after single doses of gamma-radiation and after combined treatment with 3 micrograms of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)/ml given 16 hr prior to irradiation. DNA damage and repair were assayed using ...
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Mammalian cells treated during mitosis with the anticancer drug bleomycin cannot recover from potentially lethal damage. G1- and S-phase cells treated in a similar manner can recover. In synchronized G1- and S-phase cells, and in asynchronous and nondividing populations, the final survival values of recovered cells have always been found to be greater than 0.2. These data suggest that a certain...
متن کاملRelationship between the Repair of Radiation-induced DMA Damage and Recovery from Potentially Lethal Damage in 9L Rat Brain Tumor Cells1
The kinetics of repair of radiation-induced DNA damage and recovery from radiation-induced potentially lethal damage (PLD) for fed plateau-phase 9L/Ro rat brain tumor cells were compared after single doses of 7-radiation and after combined treatment with 3 /tg of 1,3-bis(2-chloroethyl)-1 -nitrosourea (BCNU)/ml given 16 hr prior to irradiation. DNA damage and repair were assayed using alkaline f...
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The survival of cells from two transplantable murine tumors (NCTC 2472 fibrosarcoma and EMT6 mammary sarcoma), X-irradiated in vivo, was assayed by determining the clonogenicity of the cells in vitro. Cells from tumors kept in situ 6 or 24 hr after irradiation had higher survival than cells from tumors excised immediately after irradia tion. This increase in survival was done dependent and had ...
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To determine the relationship between ionizing radiation-induced levels of γ-H2AX foci and cell survival in cultured prostate cancer cell lines, three prostate cancer cell lines: LNCaP (wt TP53), DU145 (mut TP53) and PC3 (TP53 null), were studied. For γ-H2AX foci induction, cells were irradiated with a single dose of 2 Gy and foci levels were studied at 30 min and 24 h after irradiation. Cell s...
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ژورنال
عنوان ژورنال: International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine
سال: 1976
ISSN: 0020-7616
DOI: 10.1080/09553007614551421